I prefer to stay at the Dai-Ichi Seafort when on business. Besides being conveniently close to my office, it's also cleaner and quieter than Le Meridien Pacific.
It's got a good selection of cafes and restaurants. There are 2 Italian restaurants, sushi-ya, ramen-ya, etc etc. If you're willing to spend, there's a very good Teppanyaki restaurant on the 24th floor of the hotel. The menu is seasonal and typical of Teppanyaki restaurants, the chef prepares the food in front of you, so it's served piping hot within seconds of cooking. There's also a small cozy lounge next to this restaurant, which has a good selection of cocktails, and a wonderful view of the Tokyo Bay skyline.
The hotel is connected to a shopping mall, Seafort Place. If you like the knick-knack store Frou Frou, there's an outlet right on the ground floor. Good place to pick up stylish homeware, e.g. bath salts, frames, cups, plates and the like. If you're in need of some quick cash, you will find Citibank ATMs on the ground floor as well.
As for transportation, Seafort Place (the mall) is connected to Tennozu Isle monorail station. From here, you can catch the monorail to Hamamatsu-cho station, where you can connect to the JR trains. If you want to get onto the JR directly, you can walk 5 mins to the JR Tennozu Isle station, which is on the Rinkai line.
Unique Quality: Slight problem with the hotel is the infrequent runs of the Airport Limousine. There are only 4 runs a day, so you end up waiting at the airport for the bus to get here (esp if you get in first thing in the morning), or you have to wake up really early to catch the bus to Narita when you depart.
But there's hope in sight. I usually catch the Airport Limousine to any hotel in the Shinagawa area, then take a cab to the hotel. Taxi fare should be about 1000 yen.
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Address: 2-3-15 Higashi-shinagawa, Shinagawa, Tokyo Prefecture, 140-0002, Japan