On our first trip to Prague in 2002 we had already stayed in Florenc (in another hotel). It is not the nicest neighbourhood in Prague, but it is just one subway stop from Namesti Republiky and two from Mustek or Muzeum.
This time (August 2004) we decided to give Hotel Florenc a try. it is located 20 meters from the subway entrance and the room was very modest but clean and quite large (for european standards). There was a safe in the reception to store our valuables and the front-desk staff was very helpful, giving us useful travel information.
They can also arrange for taxis and anything else you might need. The guy we spoke to really knew his way around.
One thing to remember about the Czech Republic. Displayed prices are always the maximum you should pay, browsing around the internet or even negotiating at the Hotel will give you a good deal, not only on the room rate but also the taxi fare, etc. Prague is MUCH more expensive now than it was in 2002.
Directions: Right next to Florenc subway station
Bartolomejska 9, StarÃ© Mesto, Prague
Trziste 9, Prague
Hostivitova 3, Prague
U Slate Studne 166/4, Praha 1-Mala Stana, 118 00 Czech Republic
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Address: Krizikova 11, Praha 8, Prague, Bohemia, 18600, Czech Republic