Our family (mom, dad, daughter, son, daughter-in-law, daughter and son-in-law) stayed at the Internazionale Domus in Rome in 2003 and again in 2005. The small apartments worked great for our mix of family. The cost was VERY reasonable as compared to three or four hotel rooms. We stayed in the Pierret Apartment and two of their smaller suites. The Pierret overlooks the Piazza de Spagna and the view is spectacular. The large living room has a 400 year old mural on the ceiling.
We could walk to just about anywhere from this location. The metro stop (PIazza de Spagna) is at the base of the building for the longer trips.