Locanda dei Guelfi B&B

I've taken both cabs and buses to get between the airport and Florence city center. Cabs are of course the most convenient option but will cost btw 20 and 30 Euros. The bus on the other hand was also surprisingly easy and cost only 4 Euros. It goes from the airport to the Florence train station (which is in the center of the city). The only drawback is if your hotel is far from the train station you may need to catch a cab from there. Trucking luggage down some of the city streets (especially the narrow cobblestone ones) could be difficult.