Considering the St. Regis Hotel, San Francisco in San Francisco?
A VT member wrote the following comment about visiting San Francisco:
Best Area to Stay in San Francisco by risse73
I love to stay around the Union Square area whenever I am in San Francisco. It is the best place to be as you are right in the heart of all the action and you can easily navigate the city on foot or via public transport from there.
Goodluck & do enjoy your visit to beautiful SF!