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26 Hotels
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1.
Hotel Class 
695 Peppers Ferry Road, Wytheville
- 1 review and 83 opinions: "New hotel, very clean and comfortable. We stayed for 5 nights, and would go back again. Staff was..."
Good for: Road Trip, Family Travel, Business Travel
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2.
Hotel Class
140 Lithia Rd, Wytheville
- 1 review and 20 opinions: "We stayed there 12 November 2005. The rooms were HUGE, CLEAN and very comfortable. The bathroom..."
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Fairfield Inn & Suites Wytheville
Hotel Class
200 Marriott Way, (opening April 2008), Wytheville
- 72 opinions
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11.
Red Roof Inn & Suites Wytheville
Hotel Class
1900 East Main St, I-81/I-77 at exit # 73, Wytheville
- 48 opinions
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