About 2hrs north of Manizales, along a very winding road, is a little village, perched atop a hill overlooking the surrounding areas, called Salamina. Salamina is what they call a 'pueblo paisa', a typical little village in the 'zona cafetera', the coffee growing region of Colombia. It is one of the oldest towns in the region, and due to it's isolation, has been able to maintain a very typical feel.
Most people come here on a daytrip from Manizales. You could also use it as a stopping point to break the journey between Medellin and Manizales, or even spend a few days as I did.
Check out my Salamina page for more.