Daily buses leave Karachi for Thatta. However in my opinion this is a road trip best enjoyed if you have your own car, or rent a van/car. It is a straight - properly carpeted road that takes you to Thatta from Karachi. It takes approx. 2 hours to reach; depending upon how many stops you make on the way for sightseeing.
Beware of overtaking buses/trucks as well as speed breakers when entering small hamlets/villages/cities.
Updated May 17, 2009
For Car rental, the rates vary depending upon the vehicle, provider, and condition. You should expect around USD200 ~ USD 400 for whole day rental (I m not very sure about it since I drove by my own car).
For your own car, it may not be as expensive and the cost will be approximately USD40 for the fuel and etc. for the whole drive.
Written Jul 8, 2004
Bus fare in quite nominal of less than Rs.150 (approx. USD.3) one side, yet the journey may be exhausting and uncomfortable.
For bus, go to Malir or Qaid Abad stop and take any bus that goes either to Thatta or Hyderabad.
Written Jul 8, 2004
Thee are only two ways you can go to Thatta and adjacent areas. These are either by public transport using bus or hiring van, car for a day with or without driver (self-drive).
National Highway, N-5 is two lane road in fair, if not good, condition and you can travel at the speed between 60 ~ 90 kms/hrs depending upon the condition of road. For return, if taken on Super Highway (M-9), the road condition is very good.
Updated Jul 8, 2004
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Reviews and photos of Thatta attractions posted by real travelers and locals. The best tips for Thatta sightseeing.

Thee are only two ways you can go to Thatta and adjacent areas. These are either by public transport using bus or hiring van, car for a day with or without...
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1

In local dialect, Thatta is also known as Thatto. It was also once called the El Dorado of the east. Many years ago this city was important for being Sindh's capital city and a center where Islamic......
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Thatta - EI Dorado of the east

Thatta, once called the EI Dorado of the east, is a small city in the east of Karachi, some 98 km (60 miles) away from Karachi on two-lane National Highway (N-5) that connects Karachi, Thatta and...
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Thatta - A great historical City

Thatta is the prominent city of Sind province. It is about 100 km away from Karachi. Its history is very rich. It remaind capital of Sind since 1400 to 1800 AD. There are various activities for...
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I've got some interesting experiences in Thatta. I'd love to share with you the 0 tips I've written, the 15 photos uploaded, and 3 travelogues I've created.
5

Taking advantage of the long weekend last week, I made a plan with friends to discover some places around Karachi including Chowkundi Tombs, Haleji Lake, Shahjahan Mosque, Makli, and Bhanbore (ruins...
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