From Melbourne you take the Eastern Freeway until the Nunawading exit. Turn right into Springvale Road and then left onto Whitehorse Road, which later becomes the Maroondah Highway. Keep going straight on this highway to Lilydale and then the B360 takes you to Healesville.
Here is a map of part of Victoria, showing in detail Melbourne's Port Phillip Bay. To the South East bottom of the screen, is Phillip Island, home of the Fairy Penguins (and one weekend each October, the Australian Motorcycle Grand Prix!)
Here is a map showing more of the South East of Victoria, from Melbourne - Gippsland (including Wilson's Promontory)
If you need to find a Taxi, they're nice and bright and easy to spot.
Here's one with the Flinders St Railway Station in the background.
It's easy to get around Melbourne using the public transport system. Purchase a Metcard to get you into town and around town all day or just for a few hours.