We got to Prague by bus. But Prague has very good train connections, so I recommend you to travel to Prague by rail.
By metro. the Mustek station is right in the centre (Vaclovske namesti), so....
You don't really want to travel this way, DO YOU? Rent a car, take a train, take a local bus but try not to go with a large group of tourists.
There are ways to come to Prague. Fly, train, drive or bus.
Prague has a good underground Metro system that will get you around most parts of the city. The line consists of the A,B and C lines.
Metro will be the best. And with this ticket you can use all the public transportations. This is 2-days ticket. And of course you can have other options such as 1-day pass. Have a look at the ticket!
A relaxing way to see the main part of Prague is by carriage. In the Market Square they are lined up, waiting for customers.
by train you can relax and enjoy the pittoresk places and the beautifull nature of czech, like mountains and lakes.