Museum De Pont, Tilburg
This is where I learned to appreciate modern art. This museum is housed in a former wool factory and has a collection of art by famous and not so famous artists. Some of the exhibits are mysterious, others are funny, others are just beautiful while some I find crap. A must-visit if you like modern art, but still recommended if you don't. You just may like it after your visit, like I did. Also look out for temporary exhibitions, these are often very good.
De Pont is a museum for contemperary art and situated in an old wool factory. If you like this kind of art it's sure something not to miss. The museum has some exceptional works of modern artists.