This was a major station on the West coast line and is still impressive. Built in 1847 the 4 tracks that run thourh the centre are spanned by a glass roof and a footbridge.
In addition to the mainline trains (by Virgin), there are lines to Newcastle, Dumfries and the famously scenic Settle line which still operates a limited steam service.
We hired a car and drove around the UK... It was easy for us since we are used to driving on the left side of the road, although the strange road signs had us wondering a few times... :)
The roads were all very good except for the traffic jams around the larger cities...try to avoid 'peak' hours if you can help it.
The distances between cities in the UK are all fairly short, it doesn't really take too long to get anywhere except if you stop for photos every few minutes. ;)