Trains for Stoke on Trent are run by Virgin Trains on the line between Euston and Manchester Trains leave Euston at 05 and 35 minutes past the hour during the working day (10 and 53 minutes past the hour on Saturdays & 05 and 28 minutes past the hour on Sundays). The journey takes just over an hour and a half on weekdays. I travelled on a Friday evening and found the train very busy, with plenty of people standing or sat on the floor, so it is important to book a seat at busy times if you don’t want to stand. The train was delayed in arriving at the platform, then they actually announced the wrong platform at first and it was really amazing to see such a huge mass of people swarm to one end of the station then move like a herd of animals stampeding to the platform, through the barriers.
To return to Kings Cross, there are trains leaving Stoke on Trent at 50 and 23 minutes past the hour during the working day (21 and 55 minutes past the hour on Saturdays & 21 and 48 minutes past the hour on Sundays).
Costs start at £46 for an off peak standard saver single rising to £250 for a peak time Virgin business day return. (First class/business is available on most services.) Discounts may be obtained with a variety of railcards.
The ticket office is open throughout the day and the station is staffed 24 hours. There is a good number of eating/toilet facilities available within the station, which is listed by National Rail Enquiries as having a variety of accessibility options, with staff help available for passengers with additional needs. Parking is available, as is cycle storage. An online queries form is available on the website.
Be warned the city round peak times is a nightmare.
Ongoing works on the A500 or 'D' road as the locals call (our main link road) will add plenty of time and frustration especially if you are trying to get in to the city centre or beyond.
For example I live approximately 40 minutes from Manchester city centre. To get to Hanley (city centre) a journey of approx 10 miles will take 40 minutes peak time.
Every city has transport problems but Stoke is crap, i.e no bus lanes, cycle lanes that run for a metre then vanish!
Though we are a city, we are yet to catch up with the likes of Manchester with their trams, and have to rely on the good old bus. The bus system has recently been updated and covers all towns within Stoke-on-Trent and also local attractions. It's fairly cheap, but the buses don't run much past midnight.