Take US 1 all the way to Key West. The drive is simply beautiful. Much of it is across brides that link the many keys. On the way to Key West you could stop in Key Largo or Marathon. You also get to cross the 7-Mile Bridge (the one that I though got blown up at the end of True Lies! :-P ). Photo ops abound...
I got there by driving from Fort Lauderdale. It’s about 4 hours of actual driving time. Take the Florida Turnpike south toward Key West. The Turnpike ends at US 1 in Florida City. Follow U.S. 1 south about 22 miles to Key Largo and you are now in the Florida Keys
fly to Miami and drive down through the Keys. But 150 miles takes 3 hours at least. but seeing the blue-green water and the flora and fauna is worth the trip. Then fly home from Key West.
walking or bike
To go to Key West, take the US1 to south. You'll pass through the other Keys which are also beautiful (for what I've seen from them).
Eden House Key West
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Southernmost Hotel Key West
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