When we went, my dad rented a car and we drove from Orlando to the hotel in Lake Buena Vista. We used the car occasionally during our week there, but when going to Disney World we took the hotel shuttle.
One way to get around between sections of the park is the monorail. Since we were staying at a Disney hotel, the monorail came right through the hotel.
It is also possible to ride in the front of the monorail so you can see where you are going. We did this, and it is really neat (but the reflections make it hard to take pictures).