The Delta Blues Museum in Clarksdale showcases the history of the blues through photos, artifacts, and instruments. It features a shrine to Muddy Waters and includes his childhood cabin, along with local art and a gift shop.

The Crossroad marks the famous meeting place where blues musician Robert Johnson allegedly made a deal with the devil. It is the intersection of Highways 61 and 49, known for its historical significance and local folklore.

Cat Head Delta Blues & Folk Art is a vibrant store in Clarksdale run by Roger Stolle. It offers a wide variety of blues music, local art, and books, making it a key spot for music lovers and visitors alike.

The Rock and Blues Museum in Clarksdale showcases the history of rock and blues music. It features a rich collection of artifacts, photographs, and memorabilia that highlight the contributions of important artists and events.

Stan Streets Hambone Art Gallery showcases local art and culture. It features colorful folk art and tells the stories of the Mississippi Delta.