What you can find on this area is plenty of good museums.
for example, you`ll find four museums, the costumbrista, the golden museum the Murillo`s house and the litoral bolivian.
Fondest memory: Definitely for me is good to see something about the past of la paz and Bolivia. this street is particularly interesting because it has a lot of memories, it offers to see old houses. such as the house of Pedro Domingo Murillo, who was a hero agains the Spanish conquerors. At the end he was hung at Murillo square.
The Coca museum, up Calle Santa Cruz about 3rd left halfway down and on the right, look for it its not obvious.
As a driver I have to recommend driving (Imbex car hire). Drive very defensively and don't pay too much attention to traffic lights!
Fondest memory: The bustling city life and lack of Gringos!