Getting to Antigua from the City of Guatemala takes you about one hour and twenty minutes (may be more, depending on the traffic and the time of day) and costs 6Q if you gte on the bus on the "parrada" at 18th Calle in Zona 1. You will arrive at the bus stop behind the Mercado de Artesanias in Antigua Guatemala.
Antigua is well connected to Guatemala city or other towns like Chichicastenango, Solola or Quetzaltenango, by bus. Also there are shuttle buses to the city or the airport, the price of the shuttles is about $20.00.
I had tried to avoid guatemala city at all costs. I failed, and in the end even missed the shuttle that i had arranged to whisk me away to Antigua. I took the chickenbus, my first, and it was FINE. perhaps an hour or an hour and a half?
The chicken bus experience is a must for experiencing Central America! It will be an endearing memory, trust me! They are great. They are all brightly painted with such imagination. They are always packed, and most of the time you might have problems getting a seat. The music on the buses is great! Chicken buses are truly a part of the whole experience of Guatemala!!!
Buses arrive and depart from a large open lot beyond the market, on the town’s west side. Connections with Guatemala City are frequent, and one direct bus daily runs to Panajachel.To reach other highland towns such as Chichicastenango, Quetzaltenango and Huehuetenango, or Panajachel at any other time of day, take one of the frequent buses to Chimaltenango, on the Interamericana, and catch an onward bus from there. Or take a bus heading toward Guatemala City, get off at San Lucas Sacatepéquez and change buses there - this takes a little more time, but it’s a good road, and since you’ll be boarding the bus closer to the capital you’re more likely to get a seat (important if you want to avoid the possibility of standing for several hours).
Buses to outlying villages such as Santa María de Jesús (US$0.25, 30 minutes) and San Antonio Aguas Calientes (US$0.20, 25 minutes) depart from the bus area behind the market. It’s best to make your outward trip early in the morning, returning by midafternoon, as bus services drop off dramatically as late afternoon approaches.
They have public transportation (the very colorful buses) but I wouldn't recommend them.... though you can try it if you're staying in Guatemala city, you'll need to! 'cause a taxi would just be too expensive! (well, nothing can be 'too expensive' in Guatemala) And if you do, these buses are pretty safe, especially going from the city to Antigua, only about a 45 minute trip. But once in Antigua... the thing to do is 'walk'!!!! and enjoy the views and cobble stone streets, etc.
Guatemala shares the tradition of many Central American countries. Buses painted with colorful images. Mostly old school buses imported from the US. In Guatamela, they are called "Chicken Buses".